Parity, Breastfeeding Tied to ER ? /PR ? Breast Cancer Risk
Higher relation is compared with an increasing risk of estrogen receptor-negative/progesterone receptor-negative breast cancer in African-American women, though breastfeeding ameliorates this inauspicious effect, according to a investigate published online Aug. 16 in Cancer Epidemiology, Biomarkers Prevention.
WEDNESDAY, Aug. 17 (HealthDay News) ? Higher relation is compared with an increasing risk of estrogen receptor (ER)-negative/progesterone receptor (PR)-negative (ER?/PR?) breast cancer in African-American women, though breastfeeding ameliorates this inauspicious effect, according to a investigate published online Aug. 16 in Cancer Epidemiology, Biomarkers Prevention.
Julie R. Palmer, Sc.D., from Slone Epidemiology Center during Boston University, and colleagues examined a organisation between relation and lactation to occurrence of ER?/PR? and ER+/PR+ breast cancer in 59,000 African-American women. Data were collected from women followed in a Black Women?s Health Study between 1995 and 2009, and 457 occurrence cases of ER+/PR+ and 318 cases of ER?/PR? breast cancer, reliable by examination of pathology data, were identified.
The investigators found that aloft relation was correlated with an increasing risk of ER?/PR? breast cancer (hazard ratio [HR], 1.48; 95 percent certainty interlude [CI], 0.98 to 1.84 for 3 or some-more contra 0 births), and with a lowered risk of ER+/PR+ cancer (HR, 0.53; 95 percent CI, 0.39 to 0.73 for 3 or some-more contra 0 births). High relation was not correlated with an increasing occurrence of ER?/PR? breast cancer among women who had breastfed. However, a different association between high relation and ER+/PR+ cancer remained.
?The aloft occurrence of ER?/PR? breast cancer in African-American women might be explained in partial by their aloft relation and reduce superiority of breastfeeding relations to white women,? a authors write. ?Increased breastfeeding might lead to a rebate in a occurrence of this breast cancer subtype.?
Abstract
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